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PDE-5 is an enzyme found in trabecular smooth muscle. It catalyzes the degradation of cGMP, which results in an elevated cytosolic calcium concentration and smooth-muscle contraction (Fig. 2). PDE-5 inhibitors, therefore, block this biochemical pathway to promote erection. Eleven subtypes of PDEs have been described, with 30 isoenzymes mediating a variety of physiologic actions throughout the body.32 PDEs exhibit enormous functional diversity; at present, our understanding of PDE types 1 to 6 are considerably better than our understanding of PDE types 7 to 11.
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Erectile dysfunction is characterized by the regular or repeated inability to obtain or maintain an erection. There are several ways that erectile dysfunction is analyzed:
After all the information regarding the patient's status has been gathered, the various options in management can be discussed. This is best completed in the presence of the patient and his partner. Enough options are available that every man who wants to be sexually active can do so. These include sexual counseling if no organic causes can be found for the dysfunction, oral medications, external vacuum devices, or some type of invasive therapy, including the use of intracavernosal injection therapy or the Medicated Urethral System for Erections (MUSE), which is an intraurethral suppository. One of the most difficult aspects is teaching men that sex entails more than simply achieving an erection.
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Stop taking these medications and call a doctor or health care provider right away if you experience sudden or decreased vision loss in one or both eyes. A rare vision problem called NAION has been reported by a few men using these drugs. NAION (nonarteritic anterior ischemic optic neuropathy) causes a sudden loss of eyesight because blood flow is blocked to the optic nerve. People who have a higher chance for NAION include those who:
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"The best thing to do is to discuss things outside of the bedroom -- not right after it happens, but days or even weeks later," says sex expert Jennifer Downey, MD, a psychiatrist at New York State Psychiatric Institute and a professor at Columbia University. During this talk, Downey says make certain that your man is aware of the health problems that can be the cause of his ED, and gently suggest he talk to his doctor.
You may be relieved to learn that the risk of breast cancer from taking the birth control pill is very small, as revealed in research from the Mayo Clinic. However, there are many other side effects associated with the pill and the birth control patch. Learn more about these risks so you can make better contraceptive choices and protect your health.
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Q. What about the problem of prolonged erection?
The appropriate homeopathic remedy can help move the body and mind toward healing. A trained homeopathic practitioner is needed to identify and prescribe a deep-acting, constitutional remedy.
Look, Iím not a prude, but I kind of got enough of those freaking Viagra ads during the Major League Baseball playoffs. Theyíre really fun to watch with your 8 and 10 year old. Itís one of those cases where I appreciated how in the UK, certain types of ads simply could not be shown before a certain hour, when kids were assumed to be bed ó or in association with certain kinds of TV shows.
What about hormone shots and implants?
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